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Allogeneic bone marrow transplantation for patients with acute
nonlymphocytic leukemia
R Dinsmore, D Kirkpatrick, N Flomenberg, S Gulati, N Kapoor, J Brochstein, B Shank, A Reid, S Groshen and RJ O'Reilly
Seventy patients with acute nonlymphocytic leukemia (ANLL) underwent
allogeneic bone marrow transplantation following cytoreduction with total
body irradiation and cyclophosphamide. Thirty patients underwent
transplantation in first remission, 11 in second remission, 3 in third
remission, and 26 in relapse. At a median follow-up of 30 mo, 17 of those
in first remission and 7 of those in second remission survive in continuous
remission, compared to 1 in third remission and 3 in relapse. The 3-yr
Kaplan-Meier probability of disease-free survival among the various groups
was 55% (+/- 9.2%) for the first remission transplants, 64% (+/- 14.5%) for
second remission, 33% (+/- 20%) in third remission, and 10.3% (+/- 6.3%) in
the relapse group. Statistical analysis showed a similar survival in the
first and second remission groups that was significantly better than that
seen in the third remission and relapse groups (p less than 0.01). The
improved survival seen in the early remission groups was due to a
significant decrease in the incidence of relapse posttransplant (p less
than 0.01). These results confirm observations that a significant number of
patients transplanted in first remission may achieve extended disease-free
survival and document similar results for patients transplanted in second
remission.
Volume 63,
Issue 3,
pp. 649-656,
03/01/1984
Copyright © 1984 by The American Society of Hematology
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