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Study of Langerhans cells after allogeneic bone marrow transplantation
C Perreault, M Pelletier, D Landry and M Gyger
We assessed the number of Langerhans cells (LC) before and after bone
marrow transplantation (BMT) in 27 patients in order to study the fate and
behavior of these dendritic antigen-presenting cells following allogeneic
BMT. LC were identified using monoclonal antibody OKT6 on skin biopsies
performed on days - 10, 0, 11, 25, 39, 120, and 365. In a control group
composed of 15 healthy adults aged 20-37 yr, the mean number of LC (+/-
SEM) was 25.6 +/- 1.17/0.1 sq mm of epidermal surface. Our study shows that
pretransplant, the number of LC in patients with aplastic anemia or
leukemia was lower than that of controls. The finding of low numbers of LC
in patients with untreated aplastic anemia is suggestive of a medullary
origin of LC in man. Moreover, during the early posttransplant period,
nearly all patients present a severe deficit in LC. This deficit may delay
the maturation of their immune system. The number of LC reaches nearly
normal levels 4- 12 mo after BMT. Finally, we have noted a significant
impairment of LC reconstitution in patients with acute graft-versus-host
disease (GVHD), providing evidence that this defect may be an important
mechanism involved in acute GVHD-related immunodeficiency.
Volume 63,
Issue 4,
pp. 807-811,
04/01/1984
Copyright © 1984 by The American Society of Hematology
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