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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by von Melchner, H. Articles by Hoffken, K. Search for Related Content PubMed PubMed Citation Articles by von Melchner, H. Articles by Hoffken, K. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  T lymphocyte-mediated graft--antigraft reactivity during graft-versus- host reaction in vitro H von Melchner and K Hoffken Spleen organ cultures were prepared from lethally irradiated mice that had been injected with allogeneic bone marrow, with or without lymph node cells. These cultures were used in the analysis of graft-versus- host reactions (GVHR) in vitro. It was found that donor-derived T lymphocytes, which had been grown in an allogeneic spleen, prevented hemopoietic progenitor cells (colony-forming cells, CFC) of the recipient from differentiating in agar cultures. Furthermore, these lymphocytes were found to inhibit growth and differentiation of CFCs of the same donor. This graft-antigraft reactivity was not abolished by monoclonal anti-Thy-1 plus complement (C'), in contrast to the conventional GVHR. This indicates that the graft-versus-graft reaction depends on "de novo" generation of mature T lymphocyte effector cells from transplanted graft precursors. Volume 63, Issue 4, pp. 812-817, 04/01/1984 Copyright © 1984 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1984 by American Society of Hematology         Online ISSN: 1528-0020