Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rovigatti, U.
Right arrow Articles by Stass, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rovigatti, U.
Right arrow Articles by Stass, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Heavy chain immunoglobulin gene rearrangement in acute nonlymphocytic leukemia

U Rovigatti, J Mirro, G Kitchingman, G Dahl, J Ochs, S Murphy and S Stass

Samples of leukemic cell DNA from 14 children with acute nonlymphocytic leukemia (ANLL) and 4 human myeloid leukemia cell lines were analyzed for rearrangement in the heavy chain region of the immunoglobulin gene. The diagnosis of ANLL was confirmed in all patients by morphological, cytochemical, and immunologic studies. By restriction endonuclease digestion and hybridization with cloned heavy chain immunoglobulin gene probes for the constant (Cmu) and joining (JH) regions, the DNA of 2 patients and 1 cell line (ML-1) was found to contain rearrangements. The DNA from the remaining 12 patients and 3 cell lines was not rearranged (germline configuration). Both patients with apparent immunoglobulin gene rearrangement achieved complete remission on therapy for ANLL. Immunoglobulin gene rearrangement in phenotypically defined ANLL suggests (1) that such changes may not be limited to lymphoid leukemia of B cell lineage, or (2) that, in some patients, the leukemic transforming event may involve stem cells capable of both B cell and myeloid differentiation.

Volume 63, Issue 5, pp. 1023-1027, 05/01/1984
Copyright © 1984 by The American Society of Hematology


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Pathol.Home page
S M Kröber, A Greschniok, E Kaiserling, and H-P Horny
Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens
Mol. Pathol., April 1, 2000; 53(2): 83 - 87.
[Abstract] [Full Text]

Home page
 Arch DermatolHome page
Regressing Atypical Histiocytosis: The Controversy Continues
Arch Dermatol, March 1, 1988; 124(3): 319 - 320.
[Abstract] [PDF]

Home page
 ScienceHome page
U Rovigatti, D. Watson, and J. Yunis
Amplification and rearrangement of Hu-ets-1 in leukemia and lymphoma with involvement of 11q23
Science, April 18, 1986; 232(4748): 398 - 400.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
T. A. WALDMANN, S. J. KORSMEYER, A. BAKHSHI, A. ARNOLD, and I. R. KIRSCH
Molecular Genetic Analysis of Human Lymphoid Neoplasms: Immunoglobulin Genes and the c-myc Oncogene
Ann Intern Med, April 1, 1985; 102(4): 497 - 510.
[Abstract] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 1984 by American Society of Hematology         Online ISSN: 1528-0020