Immunologic injury to vascular endothelial cells: effects on release of
prostacyclin
JC Goldsmith and JJ McCormick
Prostacyclin is released from cultured and ex vivo bovine vascular
endothelium following sublethal immunologic injury by a heterologous
antibody to endothelial cells developed in rabbits. This release was
dependent on calcium and complement and was not enhanced by the presence of
platelets. Prostacyclin release was diminished 1-2 hr after the injury, but
recovered fully following reculture of the endothelial cells for 72 hr.
Volume 63,
Issue 5,
pp. 984-989,
05/01/1984
Copyright © 1984 by The American Society of Hematology