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Next Article 
Predictive factors for acute graft-versus-host disease in patients
transplanted with HLA-identical bone marrow
DS Bross, PJ Tutschka, ER Farmer, WE Beschorner, HG Braine, ED Mellits, WB Bias and GW Santos
To identify predictive parameters for incidence and severity of acute
graft-versus-host disease (GVHD), 136 patients, transplanted with
histocompatible marrow as therapy for aplastic anemia and hematologic
malignancies, were examined using univariate and multivariate analyses. The
risk of GVHD increased in patients with acute lymphocytic leukemia (p less
than 0.05), in sex-mismatched donor-recipient pairs (p less than 0.01), and
in patients older than 23.7 yr (p less than 0.05). No other commonly
observed factors appeared to have any relationship to GVHD except the
presence of certain alleles. The presence of a Cw4 allele or of the Bw21
specificities B49 and B50 were associated with significantly increased
risks of GVHD (p less than 0.05), whereas the presence of Aw19 (or the
related specificities A29, Aw30, Aw31 , Aw32, Aw33 ) was associated with a
significantly decreased risk (p less than 0.01). Using these factors, a
regression equation can be constructed that estimates the risk of a given
patient to develop clinically significant acute GVHD.
Volume 63,
Issue 6,
pp. 1265-1270,
06/01/1984
Copyright © 1984 by The American Society of Hematology
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