|
|
 Previous Article | Table of Contents | Next Article 
Abnormal expansions of polyclonal large to small size granular lymphocytes:
reactive or neoplastic process?
G Semenzato, G Pizzolo, A Ranucci, C Agostini, M Chilosi, I Quinti, G De Sanctis, B Vercelli and F Pandolfi
Morphological, immunologic, and functional properties of peripheral blood
cells from two patients with chronic proliferations of granular lymphocytes
are described. Cells from both patients showed a heterogeneous pattern from
both a morphological and immunologic standpoint, indicating a polyclonal,
rather than a monoclonal, expansion of these cells. In fact, both large and
small-to-medium-sized granular lymphocytes were observed, and different
percentages of positivity were found in the analysis with a large panel of
monoclonal antibodies. Serologic and histologic features support the
hypothesis that this lymphocytosis could be secondary to bacterial or viral
infections rather than a primary event, suggesting that these patients may
have chronic reactive immunoregulatory disorders.
Volume 63,
Issue 6,
pp. 1271-1277,
06/01/1984
Copyright © 1984 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
W. G. Morice, P. J. Kurtin, A. Tefferi, and C. A. Hanson
Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B
Blood,
January 1, 2002;
99(1):
268 - 274.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lima, J. Almeida, A. H. Santos, M. dos Anjos Teixeira, M. del Carmen Alguero, M. L. Queiros, A. Balanzategui, B. Justica, M. Gonzalez, J. F. San Miguel, et al.
Immunophenotypic Analysis of the TCR-V{beta} Repertoire in 98 Persistent Expansions of CD3+/TCR-{alpha}{beta}+ Large Granular Lymphocytes : Utility in Assessing Clonality and Insights into the Pathogenesis of the Disease
Am. J. Pathol.,
November 1, 2001;
159(5):
1861 - 1868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. C. Chan, E. F. Winton, and T. A. Waldmann
Lymphocytosis of Large Granular Lymphocytes
Arch Intern Med,
June 1, 1986;
146(6):
1201 - 1203.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. J. WALLIS, T. P. LOUGHRAN Jr., M. E. KADIN, E. A. CLARK, and G. A. STARKEBAUM
Polyarthritis and Neutropenia Associated with Circulating Large Granular Lymphocytes
Ann Intern Med,
September 1, 1985;
103(3):
357 - 362.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. P. LOUGHRAN Jr., M. E. KADIN, G. STARKEBAUM, J. L. ABKOWITZ, E. A. CLARK, C. DISTECHE, L. G. LUM, and S. J. SLICHTER
Leukemia of Large Granular Lymphocytes: Association with Clonal Chromosomal Abnormalities and Autoimmune Neutropenia, Thrombocytopenia, and Hemolytic Anemia
Ann Intern Med,
February 1, 1985;
102(2):
169 - 175.
[Abstract]
[PDF]
|
|
|
|
|
