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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kelton, J. G. Articles by Rooney, P. J. Search for Related Content PubMed PubMed Citation Articles by Kelton, J. G. Articles by Rooney, P. J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The relationship among platelet-associated IgG, platelet lifespan, and reticuloendothelial cell function JG Kelton, CJ Carter, C Rodger, G Bebenek, J Gauldie, D Sheridan, YB Kassam, WF Kean, WW Buchanan and PJ Rooney Platelet-associated IgG (PAIgG) has been reported to be elevated in nonthrombocytopenic patients who have a normal platelet lifespan. This has been interpreted as indicating that PAIgG is a nonspecific finding in these patients and not a determinant of platelet survival. It is important to recognize that the reticuloendothelial (RE) system plays an important role in the clearance of antibody-sensitized cells. In this study, we related the level of PAIgG and the platelet lifespan to the RE function in patients with: (A) idiopathic thrombocytopenic purpura (ITP), and (B) five patients with elevated levels of PAIgG yet normal or near-normal platelet counts. RE function was assessed by measuring the clearance of autologous chromium-labeled red cells sensitized with a precise amount of alloantibody (2,000-3,600 molecules of IgG/cell). Eight patients with immune thrombocytopenia had significantly shortened platelet survivals (less than 2-113 hr). In contrast, the five patients with elevated PAIgG, yet normal or near- normal platelet counts, all had normal autologous platelet survivals (186-222 hr). These patients also had significantly impaired clearance of IgG-sensitized red cells, with an average of 85% of the infused red cells remaining in the circulation at 60 min (normal 42% +/- 14%, n = 10). In this study, every patient with elevated PAIgG and normal RE function had a shortened platelet lifespan. Those patients with elevated PAIgG and impaired RE function did not invariably have a shortened platelet lifespan. The observation that the PAIgG is elevated in some patients whose platelet survival is normal does not indicate that PAIgG is not biologically relevant. It indicates that these patients may have RE blockade and do not clear IgG-sensitized cells. Volume 63, Issue 6, pp. 1434-1438, 06/01/1984 Copyright © 1984 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. G. WEST and S. C. JOHNSON Danazol for the Treatment of Refractory Autoimmune Thrombocytopenia in Systemic Lupus Erythematosus Ann Intern Med, May 1, 1988; 108(5): 703 - 706. [Abstract] [PDF]

	Copyright © 1984 by American Society of Hematology         Online ISSN: 1528-0020