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Autoantibodies against platelet glycoprotein Ib in patients with chronic
immune thrombocytopenic purpura
VL Woods , Y Kurata, RR Montgomery, P Tani, D Mason, EH Oh and R McMillan
The present studies provide direct evidence that some patients with chronic
immune thrombocytopenic purpura (ITP) have autoantibodies reactive with
platelet glycoprotein Ib ( GPIb ). Microtiter wells coated with a
monoclonal antibody that recognized GPIb were reacted with either platelet
extract or a control cell extract. After washing and incubating with test
plasma, well-bound IgG was quantitated using radioactive anti-IgG. When
compared to plasma from normal subjects, plasma from 3 of 106 patients with
chronic ITP had significantly increased quantities of IgG bound to
microtiter wells reacted with platelet extracts. Negative results were
obtained with the remaining 103 patients with chronic ITP and 59 patients
with a variety of other platelet disorders. Plasma from two of the three
positive patients precipitated a protein from 125I-surface-labeled platelet
extract with a molecular weight similar to GPlb . One of the three patients
with anti- GPlb antibody also had demonstrable autoantibodies to the
platelet glycoprotein llb / llla complex.
Volume 64,
Issue 1,
pp. 156-160,
07/01/1984
Copyright © 1984 by The American Society of Hematology
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