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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stivrins, T. J. Articles by Purtilo, D. T. Search for Related Content PubMed PubMed Citation Articles by Stivrins, T. J. Articles by Purtilo, D. T. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7 TJ Stivrins, RB Davis, W Sanger, J Fritz and DT Purtilo Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder. Volume 64, Issue 1, pp. 173-176, 07/01/1984 Copyright © 1984 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. D. D'Andrea and M. Grompe Molecular Biology of Fanconi Anemia: Implications for Diagnosis and Therapy Blood, September 1, 1997; 90(5): 1725 - 1736. [Full Text] [PDF]

	Copyright © 1984 by American Society of Hematology         Online ISSN: 1528-0020