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Marrow harvesting from normal donors
CD Buckner, RA Clift, JE Sanders, P Stewart, WI Bensinger, KC Doney, KM Sullivan, RP Witherspoon, HJ Deeg and FR Appelbaum
The experience at a single institution in harvesting marrow for allogeneic
transplantation on 1,270 occasions from 1,160 normal donors is presented in
detail, together with an analysis of all the donor complications. Four
donors were less than 2 years old, and the youngest was 6 1/2 months. No
special difficulties were encountered with these young donors.
Hospitalization time was three days or less for 99% of the procedures. Six
donors had life-threatening complications; three of a cardiopulmonary and
two of an infectious nature, and one cerebrovascular embolic episode.
Significant operative site morbidity, usually transient neuropathies,
occurred in ten procedures. Ten percent of the donations were associated
with transient postoperative fever of unknown origin. Increasing donor age
was associated with a reduction of the cellularity of the marrow harvest.
The use of stored autologous blood permitted the avoidance of blood bank
transfusion in 81% of males, 69% of females, and 50% of children. It was
concluded that the procedure was associated with a very low risk of
complication, but that the involvement of normal donors in such an
operation justifies stringent monitoring.
Volume 64,
Issue 3,
pp. 630-634,
09/01/1984
Copyright © 1984 by The American Society of Hematology
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