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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de la Fuente, B. Articles by Hoyer, L. W. Search for Related Content PubMed PubMed Citation Articles by de la Fuente, B. Articles by Hoyer, L. W. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The idiotypic characteristics of human antibodies to factor VIII B de la Fuente and LW Hoyer We have prepared an antiidiotype antibody that specifically reacts with and inactivates a human autoantibody to factor VIII (VIII:C). The antiidiotype specificity of this rabbit antibody was evident in solution, as specific inhibition of anti-VIII:C activity, and in solid- phase studies. The antiidiotype antibody inhibited both plasma anti- VIII:C and Fab' fragments prepared from that plasma's IgG. Although the antibody had a greater inhibitory effect on the anti-VIII:C used for immunization than it did for other anti-VIII:C, partial inhibition was identified with ten of 25 other human anti-VIII:C. The demonstration that antiidiotype antibodies can be prepared to human anti-VIII:C indicates the feasibility of this approach to the immunochemical characterization of human anti-VIII:C inhibitors. Moreover, antiidiotype reagents have a potential role in the treatment of inhibitor patients. Volume 64, Issue 3, pp. 672-678, 09/01/1984 Copyright © 1984 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. G. Jacquemin, B. G. Desqueper, A. Benhida, L. Vander Elst, M. F. Hoylaerts, M. Bakkus, K. Thielemans, J. Arnout, K. Peerlinck, J. G. G. Gilles, et al. Mechanism and Kinetics of Factor VIII Inactivation: Study With an IgG4 Monoclonal Antibody Derived From a Hemophilia A Patient With Inhibitor Blood, July 15, 1998; 92(2): 496 - 506. [Abstract] [Full Text] [PDF]

	Copyright © 1984 by American Society of Hematology         Online ISSN: 1528-0020