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WA Andes, RD deShazo, RJ Reed, JC Harkin and NN Wang
Within the last 18 months, we have noted the development of unexplained
lymph node enlargement in otherwise asymptomatic patients with hemophilia.
Because such changes are poorly understood and, in some patient groups, may
be related to the acquired immunodeficiency syndrome (AIDS), we studied the
enlarged lymph nodes in four patients with severe factor VIII deficiency
and abnormally low peripheral blood helper-inducer/suppressor cell
(OKT4/OKT8) ratios. Surgically excised lymph nodes were studied for
histopathologic, electron microscopic, and chromosomal changes. Cell
suspensions from these and normal nodes were also studied using monoclonal
antibodies. Excised lymph nodes showed follicular hyperplasia. Electron
microscopy revealed no viral particles or vesicular rosettes. Chromosomal
aberrations included an acrocentric marker chromosome in one patient and
monosomy 21 in another. T lymphocyte ratios (OKT4/OKT8) in lymph node
suspensions were lower than those in nodes from normal controls (1.2 v 6.1)
and reflected the lymphocyte ratio in peripheral blood. Mature B cell
percentages were increased in the lymph nodes from patients with hemophilia
(38% v 27% in controls). Patients treated with factor VIII concentrates and
male homosexuals have similarities in persistent lymph node enlargement,
histologic features of follicular hyperplasia, and changes in lymph node
and circulating lymphocyte subpopulations.
This article has been cited by other articles:
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| Copyright © 1984 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
