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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pinto, A. Articles by Di Fiore, P. P. Search for Related Content PubMed PubMed Citation Articles by Pinto, A. Articles by Di Fiore, P. P. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias A Pinto, V Attadia, A Fusco, F Ferrara, OA Spada and PP Di Fiore In this study, the effects of 5-aza-2'-deoxycytidine on differentiation of human leukemic cells in primary suspension culture are reported for the first time. Morphological and functional differentiation was induced in cells from two acute monoblastic leukemias and two of three acute myeloid leukemias following repeated exposures to 1 mumol/L 5-aza- 2'-deoxycytidine. The observation that nontoxic concentrations of the drug are able to induce the in vitro differentiation of both monoblastic and myeloblastic leukemic cells into mature elements may encourage the exploitation of the differentiating properties of 5-aza- 2'-deoxycytidine in chemotherapy protocols for acute non-lymphoblastic leukemias. Volume 64, Issue 4, pp. 922-929, 10/01/1984 Copyright © 1984 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. D. Nimer Myelodysplastic syndromes Blood, May 15, 2008; 111(10): 4841 - 4851. [Abstract] [Full Text] [PDF] J. Goffin and E. Eisenhauer DNA methyltransferase inhibitors--state of the art Ann. Onc., November 1, 2002; 13(11): 1699 - 1716. [Abstract] [Full Text] [PDF] M. Daskalakis, T. T. Nguyen, C. Nguyen, P. Guldberg, G. Kohler, P. Wijermans, P. A. Jones, and M. Lubbert Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment Blood, September 26, 2002; 100(8): 2957 - 2964. [Abstract] [Full Text] [PDF] V. Santini, H. M. Kantarjian, and J.-P. Issa Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications Ann Intern Med, April 3, 2001; 134(7): 573 - 586. [Abstract] [Full Text] [PDF] P. Wijermans, M. Lubbert, G. Verhoef, A. Bosly, C. Ravoet, M. Andre, and A. Ferrant Low-Dose 5-Aza-2'-Deoxycytidine, a DNA Hypomethylating Agent, for the Treatment of High-Risk Myelodysplastic Syndrome: A Multicenter Phase II Study in Elderly Patients J. Clin. Oncol., March 1, 2000; 18(5): 956 - 956. [Abstract] [Full Text] [PDF] A. T. Ferguson, P. M. Vertino, J. R. Spitzner, S. B. Baylin, M. T. Muller, and N. E. Davidson Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2'deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells J. Biol. Chem., December 19, 1997; 272(51): 32260 - 32266. [Abstract] [Full Text] [PDF] V. Gattei, A. Celetti, A. Cerrato, M. Degan, A. De Iuliis, F. M. Rossi, G. Chiappetta, C. Consales, S. Improta, V. Zagonel, et al. Expression of the RET Receptor Tyrosine Kinase and GDNFR-alpha in Normal and Leukemic Human Hematopoietic Cells and Stromal Cells of the Bone Marrow Microenvironment Blood, April 15, 1997; 89(8): 2925 - 2937. [Abstract] [Full Text] [PDF]

	Copyright © 1984 by American Society of Hematology         Online ISSN: 1528-0020