Nonhuman primates express human leukemia-associated antigens
JM Pesando and TA Conrad
Serologic studies using four murine monoclonal antibodies specific for the
common acute lymphoblastic leukemia antigen (CALLA) and five monoclonal
antibodies specific for the gp24 surface antigen indicate that these
leukemia-associated antigens are present on cells of comparable tissues in
man and in four nonhuman primates. As in man, adherent cell populations
obtained from skin, lung, and bone marrow of Macaca fascicularis, M
mulatta, M nemestrina, and Papio cynocephalus react with these antibodies.
Similarly, granulocytes from both man and these nonhuman primates bind
CALLA- and gp24-specific antibodies. Radioimmune precipitation experiments
confirm the identity of these antigens. Our studies suggest that nonhuman
primates can be used to screen serologic reagents to leukemia-associated
antigens for potential toxic effects on normal tissues prior to their use
in man. Similarly, nonhuman primates could be employed to assess the
possible role of antigen-positive stromal cells in the reconstitution of
bone marrow following transplantation.
Volume 64,
Issue 5,
pp. 1074-1078,
11/01/1984
Copyright © 1984 by The American Society of Hematology
