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Platelet-derived growth factor promotes polymorphonuclear leukocyte
activation
DY Tzeng, TF Deuel, JS Huang, RM Senior, LA Boxer and RL Baehner
The platelet-derived growth factor (PDGF) has several well defined
important biologic activities. Platelet-derived growth factor is the major
mitogen in human serum for cells of mesenchymal origins; it is a potent
chemoattractant protein for human monocytes, neutrophils, fibroblasts, and
smooth muscle cells; and has been implicated in transformation by simian
sarcoma virus and perhaps in transformation by other agents as well. In
this article, PDGF has been shown to stimulate activation of human
peripheral blood neutrophils defined by loss of membrane associated calcium
as reflected by loss of chlortetracycline fluorescence, release of
superoxide anion and specific granule enzymes, and enhanced neutrophil
adherence and aggregation. These responses occurred in a dose-dependent
fashion at concentrations of PDGF between 10 ng/mL (0.4 nmol/L) and 40
ng/mL (1.5 nmol/L) and were comparable to effects obtained with optimal
concentrations of fMLP and C5a. Degranulation induced by PDGF was selective
for secondary (specific) granules and not primary (azurophil) granules.
Platelet-derived growth factor thus is ideally suited for a pivotal role in
attracting inflammatory cells locally and initiating neutrophil activation
at sites of blood vessel injury. Platelet-derived growth factor or a
closely related protein also may play an important role in attracting and
activating neutrophils in association with inflammatory tumors.
Volume 64,
Issue 5,
pp. 1123-1128,
11/01/1984
Copyright © 1984 by The American Society of Hematology
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