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Two-cycle timed-sequential chemotherapy for adult acute nonlymphocytic
leukemia
WP Vaughan, JE Karp and PJ Burke
Based on a series of clinical and laboratory studies of leukemia cell
kinetics and responses to chemotherapy, we have developed an intensive
timed-sequential regimen of daunorubicin and high-dose infusion 1-beta-
D-arabinofuranosyl cytosine for the treatment of adult acute nonlymphocytic
leukemia. Of the first 34 patients achieving complete remission (CR) with a
single cycle of this therapy, four (12%) remain in complete remission
without further therapy after a minimum of five years of follow-up.
Treatment of relapsed patients with a second course of the same regimen at
relapse and no chemotherapy in second remission increased to seven (21%)
the number of patients expected to remain in remission for four years or
more from their last chemotherapy. Beginning in 1980, however, we gave all
consenting adults a second cycle of this chemotherapy in early first
remission. Of the first 25 patients treated with a second cycle of this
chemotherapy in early first remission, there was one toxic death, but 11
patients (44%) remain in CR with a median follow-up of almost three years.
Volume 64,
Issue 5,
pp. 975-980,
11/01/1984
Copyright © 1984 by The American Society of Hematology
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