Decrease in generation of reactive oxygen species by neutrophils from
patients with infectious mononucleosis: role of suppressor T lymphocytes
Y Niwa, T Sakane, Y Miyachi, T Kanoh and K Somiya
We assessed the generation of reactive oxygen species (ROS: O2-, H2O2, OH .
, chemiluminescence) by neutrophils and monocytes from six patients with
infectious mononucleosis, ten patients with other viral diseases, and ten
normal controls. Neutrophils from infectious mononucleosis patients showed
markedly decreased generation of all reactive oxygen species, compared with
the two control groups; this abnormality persisted for four to eight weeks
after disease onset. Monocytes from these patients generated normal levels
of ROS. Normal neutrophils incubated with T lymphocytes from infectious
mononucleosis patients generated significantly less of each ROS than did
those incubated with T cells from either control group. T cell-mediated
suppression of ROS generation required both OKT4+ cells from infectious
mononucleosis patients and OKT8+ cells from either patients or normals. We
conclude that the generation of reaction oxygen species in neutrophils is
suppressed in patients with infectious mononucleosis, at least in part, by
interacting subsets of T lymphocytes.
Volume 64,
Issue 5,
pp. 994-999,
11/01/1984
Copyright © 1984 by The American Society of Hematology
