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Oncogene expression in human leukemia
M Blick, E Westin, J Gutterman, F Wong-Staal, R Gallo, K McCredie, M Keating and E Murphy
The transforming genes of retroviruses (v-onc) are derived from normal
cellular genes referred to as proto-oncogenes. These cellular genes have
the capacity for conversion to oncogenes (c-onc) that are capable of
inducing or maintaining the transformed state when they are overly
expressed or altered by mutation or rearrangement. To study the possible
involvement of these genes in human leukemia, we have analyzed their
expression in a variety of fresh samples. We found that a number of
oncogenes are expressed in different leukemic types and that although the
transcript size did not vary for each gene, the copy number did. The myc
gene (2.4 kb transcript) and the rasHa gene (1.5 kb transcript) were
universally expressed. But in contrast to rasHa, the myc signal intensity
varied. Myb (4.5 kb transcript) was expressed in all samples except B cell
diseases. We detected low levels of abl expression (multiple mRNA species)
in all leukemic types analyzed. Sis gene (4.2 kb transcript) expression was
restricted to one patient sample with chronic myelogenous leukemia in blast
transformation.
Volume 64,
Issue 6,
pp. 1234-1239,
12/01/1984
Copyright © 1984 by The American Society of Hematology
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