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Multi-CSF-dependent colony formation by cells of a murine hemopoietic cell
line: specificity and action of multi-CSF
D Metcalf
Cells of the Multi-CSF (IL-3)-dependent hemopoietic cell line 32D c13
formed colonies of varying size in agar cultures stimulated by Multi- CSF.
Colony formation was linear with respect to cultured cell numbers; colony
numbers and size increased with increasing concentrations of Multi-CSF, and
32D colonies themselves contained a high frequency of clonogenic cells.
Clonogenic 32D cells died in the absence of Multi-CSF (half-life six
hours), and most were unable to complete cell cycles in progress at the
time of withdrawal of Multi-CSF. The concentration of Multi-CSF directly
influenced the length of the cell cycle of dividing 32D cells. Purified
GM-CSF, G-CSF, or M-CSF had no capacity to support the survival or
proliferation of 32D cells. Colonies formed by 32D cells appear to offer a
useful model for analyzing the action of Multi- CSF in controlling
self-renewal by clonogenic hemopoietic cells.
Volume 65,
Issue 2,
pp. 357-362,
02/01/1985
Copyright © 1985 by The American Society of Hematology
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