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Hairy cell leukemia: a tumor of pre-plasma cells
KC Anderson, AW Boyd, DC Fisher, D Leslie, SF Schlossman and LM Nadler
Monoclonal antibodies defining B-, T-, and myeloid-restricted cell surface
antigens were used to characterize the lineage and state of differentiation
of tumor cells isolated from 22 patients with hairy cell leukemia (HCL).
These tumors were shown to be of B lineage because they strongly expressed
the B cell-restricted antigens B1 and B4 and lacked T cell- and
monocyte-restricted antigens. Moreover, the strong expression of the plasma
cell-associated PCA-1 antigen on the majority of hairy cells suggested that
these tumors correspond to later stages of B cell ontogeny. Dual
fluorescence experiments further confirmed that HCL splenocytes that
coexpressed B1 and PCA-1 demonstrated both the morphology and
tartrate-resistant acid phosphatase positivity of hairy cells. The
observation that some hairy cells either spontaneously produce
immunoglobulin (Ig) or could be induced to proliferate and secrete Ig
provides complementary support for the view that HCL is a pre-plasma cell
tumor. However, staining of hairy cells with anti-IL2R1 monoclonal
antibody, which is directed to the T cell growth factor receptor and/or
with the anti-Mo1 reagent, directed to C3bi complement receptor,
distinguish these cells from currently identified B cells.
Volume 65,
Issue 3,
pp. 620-629,
03/01/1985
Copyright © 1985 by The American Society of Hematology
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