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AS Freedman, AW Boyd, KC Anderson, DC Fisher, GS Pinkus, SF Schlossman and LM Nadler
The cellular lineage of 57 diffuse large-cell lymphomas (DLCLs) was
determined using a panel of monoclonal antibodies directed against
lineage-restricted and -associated T, B, and monocyte antigens. The
majority (82%) were of B cell lineage as determined by the expression of
sig and/or B1, with the remaining 16% being of T cell lineage and 2%, of
monocyte-myeloid lineage. By the expression of other B cell- restricted and
-associated antigens, two major and two minor subgroups could be
identified. These subgroups expressed the following phenotypes: (1)
B1+B4+sIG+B2- (51%); (2) B1+B4+sIg+B2+ (29%); (3) B1+B4+sIg-B2+ (10%); and
(4) B1+B4-sIg+B2- (10)%. The morphology of transformed lymphocytes, the
weak to absent expression of the early B cell antigens B2 and sIgD, and the
absence of the late B cell differentiation antigens PCA-1 and PC-1
suggested that these tumors were the neoplastic counterparts of normal B
cells at the mid-stages of differentiation. Further support for the notion
that B-DLCLs correspond to transformed B lymphocytes was concluded from the
observation that B cells could be identified in normal spleen that
expressed the cell surface phenotype and morphological appearance of the
majority of B- DLCLs.
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| Copyright © 1985 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
