Lysis of lymphoma cells by autologous and allogeneic natural killer cells
K Oshimi, Y Oshimi, O Yamada and H Mizoguchi
Studies were undertaken to determine whether natural killer (NK) cells
would lyse autologous and allogeneic lymphoma cells. When large granular
lymphocytes, which are known to mediate NK activity, were enriched from
peripheral blood and used as effector cells, they lysed autologous lymphoma
cells of all of eight patients tested, and those of healthy donors lysed
lymphoma cells of all of ten patients tested. The addition of interferon to
the culture medium enhanced their cytotoxicity in three of the eight
patients in the autologous effector- tumor system and in four of the ten
patients in the above allogeneic system. On the basis of the unlabeled
target competition test and the decrease in cytotoxicity with anti-NK
antibody treatment, NK cells appeared to be the main cytotoxic effector
cells for autologous and allogeneic lymphoma cells.
Volume 65,
Issue 3,
pp. 638-643,
03/01/1985
Copyright © 1985 by The American Society of Hematology
