5q- chromosome in acute leukemia with lymphoid morphology and expression of
myeloid membrane determinants
OA Haas, P Bettelheim, W Schmidmeier, H Gadner, H Ludwig, O Majdic and U Schulz
We present three patients, two children and one adult, with an unusual type
of acute leukemia. Whereas the blast cells showed lymphoid morphology with
correlating cytochemical staining, immunological phenotyping exhibited a
pure myeloid in one patient and a biphenotypic membrane marker profile in
the other two patients. Cytogenetic studies revealed a 5q- chromosome as a
common marker and additional individual changes. Two of the patients who
were treated according to acute lymphoblastic leukemia (ALL) therapy
protocols died without remission five and four weeks after diagnosis,
respectively. Despite relapsing several times, another patient survived for
over eight years. These three patients seem to represent one new subgroup
of leukemias that can only be distinguished from typical ALL by both
determination of cell surface markers and cytogenetic analysis.
Volume 65,
Issue 6,
pp. 1342-1348,
06/01/1985
Copyright © 1985 by The American Society of Hematology
