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The regulation of immunoglobulin synthesis after HLA-identical bone marrow
transplantation: VI. Differential rates of maturation of distinct
functional groups within lymphoid subpopulations in patients after human
marrow grafting
LG Lum, MC Seigneuret, N Orcutt-Thordarson, JE Noges and R Storb
This investigation uses different polyclonal activators of in vitro
immunoglobulin production to elicit immunoregulatory profiles of B cells, T
cells, T4 cells, and T8 cells from 25 recipients (13 with and 12 without
chronic graft-v-host disease [GVHD] ) after HLA-identical marrow
transplantation for aplastic anemia or hematologic malignancy. Pokeweed
mitogen, Epstein-Barr virus, herpes simplex type 1 virus, and tetanus
toxoid were used to induce immunoglobulin production as measured by a
plaque assay. Multiple defects in the various lymphoid subsets were found
in both groups of patients. There was defective b cell function, lack of T
cell or T4 cell subset helper activity, and increased T cell, T4 cell, or
T8 cell suppressor activity after stimulation with the various activators.
Inconsistent B, T, T4, and T8 cell functions in the marrow graft recipients
provide evidence for (a) different functional groups of cells within each
subset responsive to different polyclonal activators; (b) a spectrum of
immune capabilities within each phenotype lineage; (c) different patterns
of immune reconstitution for each lymphocyte subset after marrow grafting;
and (d) chronic GVHD altering recovery of in vitro functional responses to
the different polyclonal activators.
Volume 65,
Issue 6,
pp. 1422-1433,
06/01/1985
Copyright © 1985 by The American Society of Hematology
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