Lymphokine-induced phagocytosis in angiocentric immunoproliferative lesions
(AIL) and malignant lymphoma arising in AIL
CR Simrell, JB Margolick, GR Crabtree, J Cossman, AS Fauci and ES Jaffe
A factor that augmented the phagocytosis of IgG-coated ox red blood cells
by the human monocyte/macrophage line U937 was identified in cell culture
supernatants from two of two patients with angiocentric peripheral T cell
lymphomas, three of three patients with angiocentric immunoproliferative
lesions that were not frankly malignant, and one of two patients with T
lymphoblastic malignancies. The factor was not present in supernatants
derived from 14 nonangiocentric peripheral T cell lymphomas of other
histologic types nor in ten cases of B cell lymphoma and two cases of
Hodgkin's disease. A similar factor was present in the supernatants of
concanavalin A (Con A)-stimulated normal peripheral blood mononuclear cells
and in the supernatants of IL-2- dependent T cell lines derived from normal
peripheral blood. The factor had an apparent mol wt of greater than 50,000
daltons, was heat labile (100 degrees C for two minutes), and stable at pH
2.0. Its stimulation of phagocytosis was independent of any increase in
number of Fc receptors. Thus, this factor is probably not gamma-interferon.
This factor may play a pathogenetic role in the hemophagocytic syndromes
associated with certain T cell malignancies and immunodeficient states.
Volume 65,
Issue 6,
pp. 1469-1476,
06/01/1985
Copyright © 1985 by The American Society of Hematology
