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LAV/HTLV III presence in peripheral blood lymphocytes of seropositive young
hemophiliacs
ED Gomperts, P Feorino, BL Evatt, D Warfield, R Miller and JS McDougal
Recent studies indicate a high prevalence of seropositivity to the
lymphadenopathy-associated virus/human T-lymphotropic virus (type III)
among individuals with hemophilia exposed to clotting factor concentrates
prepared from large donor pools. The peripheral blood lymphocytes of 19
young seropositive patients with inherited bleeding disorders were examined
for the presence of this virus by coculture with
phytohemagglutinin-stimulated lymphocytes. Viral isolates were obtained
from six of 19 patients. While none of these patients have developed the
acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, five of
them had lymphadenopathy in two noncontiguous areas, and two showed
clinically symptomatic enlarged tonsils and adenoids. Of the 13 patients in
whom virus was not demonstrated, five were judged clinically normal and
five had mild lymphadenopathy in one anatomical area. These results suggest
that as many as 33% of hemophiliacs (six of 19 patients studied), who have
circulating antibodies to mature viral proteins, have viral-infected
peripheral blood lymphocytes capable of infecting other lymphocytes in
vitro.
Volume 65,
Issue 6,
pp. 1549-1552,
06/01/1985
Copyright © 1985 by The American Society of Hematology
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