Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fermand, J. P.
Right arrow Articles by Brouet, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fermand, J. P.
Right arrow Articles by Brouet, J. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Associated chronic lymphocytic leukemia and multiple myeloma: origin from a single clone

JP Fermand, JM James, P Herait and JC Brouet

We investigated the clonal relationship of malignant cells in a patient affected with both chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL cells and malignant plasma cells synthesized IgG1 kappa and IgA kappa molecules, respectively; these monoclonal Ig shared idiotypic determinants, providing evidence that a single clonal disease occurred in this patient. Furthermore, when leukemic CLL cells were driven to differentiate in vitro to immunoblasts and plasma cells, a switch from IgG to IgA occurred in a significant percentage of cells that were double producers. These data suggest that, in some circumstances, CLL leukemic B cells may reach a more mature state, leading to the occurrence of clinical MM.

Volume 66, Issue 2, pp. 291-293, 08/01/1985
Copyright © 1985 by The American Society of Hematology


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
V. L. Devi, K. Prabhash, M. Malathi, D.S. Madhumathi, and P.P. Bapsy
Uncommon Manifestations of Common Malignancies: CASE 2. Chronic Lymphocytic Leukemia and Multiple Myeloma in the Same Patient
J. Clin. Oncol., August 1, 2004; 22(15): 3192 - 3193.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Cerutti, H. Zan, E. C. Kim, S. Shah, E. J. Schattner, A. Schaffer, and P. Casali
Ongoing In Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells
J. Immunol., December 1, 2002; 169(11): 6594 - 6603.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Fend, L. Quintanilla-Martinez, S. Kumar, M. W. Beaty, L. Blum, L. Sorbara, E. S. Jaffe, and M. Raffeld
Composite Low Grade B-Cell Lymphomas with Two Immunophenotypically Distinct Cell Populations Are True Biclonal Lymphomas : A Molecular Analysis Using Laser Capture Microdissection
Am. J. Pathol., June 1, 1999; 154(6): 1857 - 1866.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
K. A. Foon, K. R. Rai, and R. P. Gale
Chronic Lymphocytic Leukemia: New Insights into Biology and Therapy
Ann Intern Med, October 1, 1990; 113(7): 525 - 539.
[Abstract] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 1985 by American Society of Hematology         Online ISSN: 1528-0020