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Minactivin expression in human monocyte and macrophage populations

RW Stephens, JP Golder, DR Fayle, DA Hume, AJ Hapel, W Allan, CJ Fordham and WF Doe

Adherent monolayer cultures of human blood monocytes, peritoneal macrophages, bone marrow macrophages, and colonic mucosa macrophages were examined for their ability to produce and secrete minactivin, a specific inactivator of urokinase-type plasminogen activator. All except colonic mucosa macrophages produced and secreted appreciable amounts of minactivin, but only blood monocytes were stimulated by muramyl dipeptide (adjuvant peptide) to increase production. The minactivin from each of these populations could be shown to preferentially inhibit urokinase-type plasminogen activator and not trypsin, plasmin, or "tissue"-type plasminogen activator (HPA66). A plasminogen-activating enzyme present in monocyte cultures appeared unaffected by the presence of minactivin and could be shown to be regulated independently by dexamethasone.

Volume 66, Issue 2, pp. 333-337, 08/01/1985
Copyright © 1985 by The American Society of Hematology


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  Copyright © 1985 by American Society of Hematology         Online ISSN: 1528-0020