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AM Ferraris, WH Raskind, BH Bjornson, RJ Jacobson, JW Singer and PJ Fialkow
In order to study the pattern of B cell involvement in acute nonlymphocytic
leukemia (ANLL), multiple B lymphoid cell lines were established by
Epstein-Barr virus transformation of peripheral blood mononuclear cells
from two patients with the disease who were heterozygous for the X
chromosome-linked glucose-6-phosphate dehydrogenase (G6PD). In one patient,
the progenitor cells involved by the leukemia exhibited multipotent
differentiative expression, whereas in the other patient the cells showed
differentiative expression restricted to the granulocytic pathway. In the
patient whose abnormal clone showed multipotent expression, the ratio of
B-A G6PD in B lymphoid cell lines was skewed in the direction of type B
(the enzyme characteristic of the leukemia clone) and significantly
different from the 1:1 ratio expected. It is, therefore, likely that the
neoplastic event occurred in a stem cell common to the lymphoid series as
well as to the myeloid series. In contrast, evidence for B cell involvement
was not detected in the patient whose ANLL progenitor cells exhibited
restricted differentiative expression. These findings underscore the
heterogeneity of ANLL. Clinically and morphologically similar malignancies
in these two patients originated in progenitors with different patterns of
stem cell differentiative expression. This difference may reflect
differences in cause and pathogenesis.
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| Copyright © 1985 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
