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A study of liver biopsies and liver disease among hemophiliacs
LM Aledort, PH Levine, M Hilgartner, P Blatt, JA Spero, JD Goldberg, L Bianchi, V Desmet, P Scheuer and H Popper
Hepatic histologic materials (biopsy or autopsy) and associated clinical
data from 155 hemophiliacs were collected by an ad hoc hemophilia study
group and analyzed retrospectively in an effort to determine the spectrum
of liver disease in this population and to examine the relationship between
the severity of liver disease and treatment history. Clinical information
on the frequency of complications from 126 biopsies in 115 hemophilic
patients provided a unique opportunity to assess the safety of liver biopsy
in such patients. The incidence of cirrhosis (15%) and chronic active
hepatitis (7%) was lower than previously reported. The frequency of severe
liver disease (chronic active hepatitis or cirrhosis) in patients receiving
large pooled concentrates was no greater than in patients treated
principally with cryoprecipitate or plasma. The risks of liver biopsy in
this setting are relatively high: clinically significant hemorrhage
followed 12.5% of the procedures.
Volume 66,
Issue 2,
pp. 367-372,
08/01/1985
Copyright © 1985 by The American Society of Hematology
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