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Recovery of T cell subsets after autologous bone marrow transplantation is
mainly due to proliferation of mature T cells in the graft
GC de Gast, LF Verdonck, JM Middeldorp, TH The, A Hekker, JA v.d. Linden, HA Kreeft and BJ Bast
In 22 patients with malignancies, treated with high-dose chemoradiotherapy
and autologous bone marrow transplantation (BMT), peripheral blood T cell
subsets and functions were studied. In ten cytomegalovirus (CMV)-negative
patients, CD4+ and CD8+ T cells (representing T cells of the helper/inducer
phenotype and T cells of the suppressor/cytotoxic phenotype, respectively),
recovered slowly and simultaneously. In 12 CMV-positive patients, however,
CD8+ T cells recovered more rapidly than CD4+ T cells and rose to increased
counts. No T cells with an immature phenotype (CD1+, OKT6+) were observed.
Lymphocyte stimulation by herpes simplex virus infected fibroblasts (and by
CMV-infected fibroblasts in CMV-positive patients) in contrast remained
high and even increased after BMT in both groups. These data indicate that
T cell recovery after autologous BMT is mainly due to proliferation of
mature T cells present in the BM graft and not to generation of new T cells
from T cell precursors.
Volume 66,
Issue 2,
pp. 428-431,
08/01/1985
Copyright © 1985 by The American Society of Hematology
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