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Aggressive non-Hodgkin's lymphomas in immunocompromised homosexual males
SP Kalter, SA Riggs, F Cabanillas, JJ Butler, FB Hagemeister, PW Mansell, GR Newell, WS Velasquez, P Salvador and B Barlogie
During the period from 1981 through 1984, 14 immunocompromised homosexual
males with intermediate or high-grade non-Hodgkin's lymphoma were seen at
University of Texas M.D. Anderson Hospital and Tumor Institute. Six
patients had diffuse large-cell lymphoma, seven had diffuse
undifferentiated lymphoma, and one had unclassifiable lymphoma that
suggested large-cell lymphoma. Eight patients had the acquired
immunodeficiency syndrome (AIDS) and five had the AIDS-related complex.
Kaposi's sarcoma was initially present in four patients and developed later
in two others. The patients with diffuse large-cell lymphoma were
characterized by more severely altered immune parameters, multicentric
brain mass lesions, pretherapy opportunistic infections, lower performance
status, poor response to therapy, and death in all within six months. The
undifferentiated lymphoma group had preceding generalized reactive
lymphadenopathy, less severe immune dysfunction, and excellent response to
combination chemotherapy, with survival time greater than 19 months in
three patients. Twelve of the patients had extranodal sites of lymphoma at
presentation. There is a definite trend for the development of aggressive
non-Hodgkin's lymphomas with unusual sites of extranodal involvement in
immunocompromised homosexual males, with the potential for good tolerance
to combination chemotherapy and improved survival in the subgroup without
severe concomitant opportunistic infections.
Volume 66,
Issue 3,
pp. 655-659,
09/01/1985
Copyright © 1985 by The American Society of Hematology
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