|
|
 Previous Article | Table of Contents | Next Article 
Delay in platelet recovery after bone marrow transplantation: impact of
cytomegalovirus infection
LF Verdonck, H van Heugten and GC de Gast
The effect of cytomegalovirus (CMV) infection on hematopoietic recovery
after marrow-ablative chemoradiotherapy followed by autologous bone marrow
transplantation (BMT) was studied in patients with non-Hodgkin's lymphoma
of high-grade malignancy and in patients with acute leukemia. The recovery
of platelets after autologous BMT occurred significantly quicker in
CMV-negative patients than in CMV-positive patients (platelets greater than
50,000 per cubic millimeter after 21 1/2 v 40 days, respectively). No
differences in the recovery of neutrophils were found between those with or
without CMV infection. CMV-positive patients required significantly more
transfusion support with thrombocyte concentrates than CMV-negative
patients (three v six thrombocyte concentrates). In conclusion, CMV
infections do not influence neutrophil recovery but do delay platelet
recovery. As a consequence, patients with a CMV infection, whether primary,
reactivated, or latent, require more thrombocyte concentrates, which
increases the risk of transfusion-related infections.
Volume 66,
Issue 4,
pp. 921-925,
10/01/1985
Copyright © 1985 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. B. Cines, J. B. Bussel, H. A. Liebman, and E. T. Luning Prak
The ITP syndrome: pathogenic and clinical diversity
Blood,
June 25, 2009;
113(26):
6511 - 6521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Zhuravskaya, J.P. Maciejewski, D.M. Netski, E. Bruening, F.R. Mackintosh, and S. St Jeor
Spread of Human Cytomegalovirus (HCMV) After Infection of Human Hematopoietic Progenitor Cells: Model of HCMV Latency
Blood,
September 15, 1997;
90(6):
2482 - 2491.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Mori, K. Ando, K. Tanaka, Y. Ikeda, and Y. Koga
Fas-Mediated Apoptosis of the Hematopoietic Progenitor Cells in Mice Infected With Murine Cytomegalovirus
Blood,
May 15, 1997;
89(10):
3565 - 3573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Nash, T. Gooley, C. Davis, and F. R. Appelbaum
The Problem of Thrombocytopenia after Hematopoietic Stem Cell Transplantation
Oncologist,
December 1, 1996;
1(6):
371 - 380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Shannon, M. J. Cowan, and K. K. Matthay
Pediatric Bone Marrow Transplantation: Intensive Care Management
J Intensive Care Med,
November 1, 1987;
2(6):
328 - 344.
[Abstract]
[PDF]
|
|
|
|
|
