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Platelet membrane topography: colocalization of thrombospondin and
fibrinogen with the glycoprotein IIb-IIIa complex
AS Asch, LL Leung, MJ Polley and RL Nachman
The distribution of platelet thrombospondin (TSP), fibrinogen, and
glycoproteins IIb-IIIa (GPIIb-IIIa) and GPIb were studied in resting and
activated human platelets using frozen thin-section immunoelectron
microscopy. In resting platelets, TSP and fibrinogen were found within
alpha granules and not on the platelet surface. In unstimulated platelets,
GPIIb-IIIa and GPIb were distributed diffusely over the platelet membrane
as well as within the body of the platelets. Upon thrombin or A23187
stimulation, TSP, fibrinogen, and GPIIb-IIIa colocalized on the platelet
membrane and the canalicular system as well as on pseudopodia and between
adherent platelets. GPIb distribution was unchanged by platelet activation.
The findings support the hypothesis that a macromolecular complex of
TSP-fibrinogen and GPIIb-IIIa forms on the activated platelet membrane.
Volume 66,
Issue 4,
pp. 926-934,
10/01/1985
Copyright © 1985 by The American Society of Hematology
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