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Changes in hematopoietic stem cells in bone marrow of mice with Plasmodium
berghei malaria
L Maggio-Price, D Brookoff and L Weiss
An impaired erythropoietic response to anemia has been noted in human
patients with malaria and in rodents experimentally infected with
Plasmodium berghei. We have attempted to characterize the erythropoietic
response in mice with a fatal P berghei infection, with particular emphasis
on changes in marrow hematopoietic stem cells. Mice infected with P berghei
had dramatic decreases in bone marrow cellularity, erythroblasts, BFU-E,
and CFU-E as early as 24 hours postinfection and before there was any
change in hematocrit. With development of anemia, marrows became
erythropoietic with some expansion of the CFU-E compartment, but the BFU-E
pool remained depleted and reticulocyte response was inadequate. There was
no significant change in CFU-S from marrows of malaria-infected mice one
day after infection. The lethality of malaria infection may take three
weeks to be revealed, but it may be determined within hours of the
infection by the irreparable changes in marrow erythroid stem cells.
Volume 66,
Issue 5,
pp. 1080-1085,
11/01/1985
Copyright © 1985 by The American Society of Hematology
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