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Next Article 
Lineage promiscuity in hemopoietic differentiation and leukemia
MF Greaves, LC Chan, AJ Furley, SM Watt and HV Molgaard
An increasing number of reports document instances in which individual
leukemic cells coexpress markers normally believed to be restricted to a
single lineage. This has been interpreted by McCulloch and colleagues as
aberrant programming or lineage infidelity and contrasts with earlier
suggestions that lineage fidelity of gene expression was usually maintained
in leukemia. We argue that several examples of infidelity are suspect on
technical grounds, whereas others are bona fide and require explanation,
eg, partial rearrangements and expression of Ig heavy-chain and/or T cell
receptor genes in inappropriate cells and terminal deoxynucleotidyl
transferase in leukemic myeloblasts. Individual examples of truly aberrant
gene expression may well occur in leukemia but with insufficient regularity
to be of general significance. We suggest that verifiable and consistent
examples of apparent lineage infidelity do not reflect genetic
misprogramming but rather the existence of a transient phase of limited
promiscuity of gene expression occurring in normal biopotential or
multipotential progenitors and able to be preserved as a relic in leukemic
blast cell populations that are in maturation arrest. This alternative
explanation has interesting implications for mechanisms of hematopoietic
differentiation and leads to some testable predictions.
Volume 67,
Issue 1,
pp. 1-11,
01/01/1986
Copyright © 1986 by The American Society of Hematology
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