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GM Holloway, EA O'Rear and BM Fung
The effect of perfluorochemical blood substitutes (eg, Oxypherol or
Fluosol-DA) on red cell deformability was investigated because these
emulsions are in direct contact with red cells when they are used as
temporary circulatory aids. Erythrocyte deformability was assessed by a
constant volumetric flow rate filtration method. The results of in vitro
incubation experiments indicate that perfluorotributylamine causes the
deformability of human red cells to decrease significantly in the presence
of plasma. However, there is no obvious loss in the deformability when
washed cells are used. Neither mean cell volume nor white cells appear to
be responsible for the observed effects of perfluorotributylamine.
Perfluorodecalin and perfluorotripropylamine, two perfluorochemical
compounds that are widely applied clinically, do not induce significant
changes in red cell deformability with or without plasma. These results
indicate the need for in vitro testing in the development of
perfluorochemicals as blood substitutes.
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| Copyright © 1986 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
