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Sickle cell anemia patients have low erythropoietin levels for their degree
of anemia
JB Sherwood, E Goldwasser, R Chilcote, LD Carmichael and RL Nagel
We have studied serum immunoreactive erythropoietin (SIE) levels in 28
patients with sickle cell anemia (SCA) without renal insufficiency and in
17 patients with nonhemoglobinopathy anemias of comparable severity using a
sensitive radioimmunoassay procedure. An exponential relationship between
SIE level and degree of anemia was noted in all patients. However, in
nonhemoglobinopathy anemia, a sharp rise in the SIE level occurred as
hemoglobin (Hb) levels fell below about 12 g/dL, whereas in sickle cell
patients the increase was not marked until hemoglobin fell to about 9 g/dL.
The response was more blunted in older SCA patients than in younger ones. A
linear regression model relating SIE level to Hb level, presence/absence of
SCA, and age explained 63% of the variation in SIE. We conclude that the
serum erythropoietin levels in SCA increased at a lower hemoglobin
concentration and are of a lower magnitude than that of the other anemias.
Volume 67,
Issue 1,
pp. 46-49,
01/01/1986
Copyright © 1986 by The American Society of Hematology
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