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Next Article 
The molecular biology and functions of the granulocyte-macrophage
colony-stimulating factors
D Metcalf
Rapid progress has occurred recently in characterizing the molecular nature
of the specific glycoprotein colony-stimulating factors (CSFs) controlling
the proliferation; and some functional activities of granulocytes and
monocyte-macrophages. All four known murine CSFs have been purified, and
cDNAs for two have been cloned and expressed by mammalian and bacterial
cells. Similarly, three human CSFs have been purified, and cDNAs for two
cloned and expressed. This work has opened up the exciting prospects of
testing the effects of these recombinant CSFs on hematopoiesis in vivo.
Each CSF has a broader range of hematopoietic target cells than previously
suspected, and it is now clear that the CSFs are not simply proliferative
stimuli but can also regulate the functional activity of mature cells.
There are increasing reasons to believe that these CSFs will be useful
therapeutic agents in stimulating hematopoietic regeneration in leukopenic
states and the functional activity of granulocytes and monocytes in
infections.
Volume 67,
Issue 2,
pp. 257-267,
02/01/1986
Copyright © 1986 by The American Society of Hematology
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