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Immunoglobulin gene rearrangements and expression in diffuse histiocytic
lymphomas reveal cellular lineage, molecular defects, and sites of
chromosomal translocation
KA Siminovitch, JP Jensen, AL Epstein and SJ Korsmeyer
We have examined the immunoglobulin gene configurations in cell lines from
eight patients with diffuse histiocytic lymphoma in order to establish the
cellular lineage and stage of differentiation of these lymphomas. The
presence of heavy and light chain gene rearrangements as well as heavy
chain class switching in seven cells placed these tumors within the B cell
lineage. In contrast, one cell (SU-DHL-1), which lacks B cell-restricted
surface antigens, retained germline heavy and light chain loci, indicating
that it may represent a true histiocyte or uncommitted cell. Truncated RNAs
for both the heavy and light chain immunoglobulins were responsible for the
lack of surface immunoglobulin in the SU-DHL-2 cell line. Another cell line
(SU-DHL-6), which possesses a t(14;18)(q32;q21) translocation, demonstrated
an unexpected recombination within its heavy chain gene locus that may be
the interchromosomal breakpoint.
Volume 67,
Issue 2,
pp. 391-397,
02/01/1986
Copyright © 1986 by The American Society of Hematology
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