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The detection of specific antibody formation to recall antigens after human
bone marrow transplantation
LG Lum, NA Munn, MS Schanfield and R Storb
The results of this study show that donor-derived immunity can be detected
and persists in long-term survivors with and without chronic graft-v-host
disease (GVHD) after human marrow grafting. Seventy-one marrow recipients
(60 long-term and 11 short-term survivors) were studied for the presence of
specific serum IgG antibodies to tetanus toxoid (TT), and 46 marrow
recipients (35 long-term and 11 short-term) were tested for antibodies to
diphtheria toxoid (DT) and measles virus after marrow grafting using an
enzyme-linked immunosorbent assay. Of the 60 long-term survivors, 31 were
healthy and 29 had chronic GVHD. None of the recipients were immunized to
the test antigens postgrafting. Most long-term healthy recipients exhibited
antibody titers to the recall test antigens, whereas only a minority of
those with chronic GVHD had antibody titers to recall antigens. In healthy
long-term recipients (greater than or equal to one year postgrafting) whose
donors were immune to the test antigens, 25 of 31 had titers to TT, 11 of
17 had titers to DT, and 12 of 20 had titers to measles. In recipients with
C-GVHD, 13 of 29 had titers to TT, six of 15 had titers to DT, and six of
15 had titers to measles virus. Within 100 days postgrafting, 11 of 11 had
anti-TT titers, ten of ten had anti-DT titers, and seven of eight had
antimeasles virus titers.
Volume 67,
Issue 3,
pp. 582-587,
03/01/1986
Copyright © 1986 by The American Society of Hematology
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