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AIDS retrovirus antibodies in hemophiliacs treated with factor VIII or
factor IX concentrates, cryoprecipitate, or fresh frozen plasma:
prevalence, seroconversion rate, and clinical correlations
MV Ragni, GE Tegtmeier, JA Levy, LS Kaminsky, JH Lewis, JA Spero, FA Bontempo, C Handwerk-Leber, WL Bayer and DH Zimmerman
Antibodies to the AIDS retrovirus, specifically to human T cell
lymphotropic virus, type III, and AIDS-associated retrovirus, were detected
with increasing prevalence in a population of 190 hemophiliacs from western
Pennsylvania between 1981 and 1984: 7.7% in 1981, 20.0% in 1982, 45.5% in
1983, and 62.5% in 1984. The seropositive included approximately three
fourths of those receiving factor VIII concentrate, nearly one third of
those receiving factor IX concentrate, nearly one fifth of those receiving
cryoprecipitate, and none of those receiving fresh frozen plasma. The
seroconversion rate, determined on 43 seropositive hemophiliacs from this
group who were serially sampled, was 0% in 1977, 4.7% in 1978, 4.9% in
1979, 2.6% in 1980, 10.5% in 1981, 52.9% in 1982, 87.5% in 1983, and 100%
in 1984. Of 27 seropositive for three or more years (since 1982 or before),
four (15%) have developed AIDS and seven (26%), diffuse lymphadenopathy
(ARC); of 16 seropositive for less than three years, none has developed
AIDS and three (19%) have developed ARC. The mean time from seroconversion
to onset of ARC, 0.8 +/- 0.2 years (SEM), was shorter (P less than .001)
than the time to onset of AIDS, 4.1 +/- 0.6 years. These findings confirm
the widespread presence of AIDS retrovirus and support the association of
these retroviruses with the acquired immunodeficiency syndrome and related
conditions.
Volume 67,
Issue 3,
pp. 592-595,
03/01/1986
Copyright © 1986 by The American Society of Hematology
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