|
|
 Previous Article | Table of Contents | Next Article 
Pathogenesis of B cell lymphoma in a patient with AIDS
JE Groopman, JL Sullivan, C Mulder, D Ginsburg, SH Orkin, CJ O'Hara, K Falchuk, F Wong-Staal and RC Gallo
Lymphoma occurs at increased frequency in patients with the acquired
immunodeficiency syndrome (AIDS). We studied, using serologic and molecular
techniques, one such lymphoma for (a) evidence of infection with human T
lymphotropic virus, type III (HTLV-III), and Epstein-Barr virus (EBV), (b)
monoclonal rearrangement of immunoglobulin and T cell receptor genes, and
(c) rearrangement of the c-myc oncogene. Immunoglobulin and T cell receptor
gene studies demonstrated that the tumor was of monoclonal B cell origin.
Similar to cases of Burkitt's lymphoma unrelated to AIDS, there were DNA
sequences in the lymphoma that hybridized to EBV-specific probes and
demonstrated evidence of c- myc rearrangement. HTLV-III sequences were not
detected in the malignant B cells. The pathogenesis of some B cell
neoplasms in patients with the syndrome may involve transformation by EBV
and deregulation of oncogene expression without direct infection of the
malignant B cells by HTLV-III.
Volume 67,
Issue 3,
pp. 612-615,
03/01/1986
Copyright © 1986 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
I. Guasparri, D. Bubman, and E. Cesarman
EBV LMP2A affects LMP1-mediated NF-{kappa}B signaling and survival of lymphoma cells by regulating TRAF2 expression
Blood,
April 1, 2008;
111(7):
3813 - 3820.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Cerimele, T. Battle, R. Lynch, D. A. Frank, E. Murad, C. Cohen, N. Macaron, J. Sixbey, K. Smith, R. S. Watnick, et al.
Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma
PNAS,
January 4, 2005;
102(1):
175 - 179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Wagar, M. A. Cromwell, L. D. Shultz, B. A. Woda, J. L. Sullivan, R. M. Hesselton, and D. L. Greiner
Regulation of Human Cell Engraftment and Development of EBV-Related Lymphoproliferative Disorders in Hu-PBL-scid Mice
J. Immunol.,
July 1, 2000;
165(1):
518 - 527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Teitell, M. A. Damore, G. G. Sulur, D. E. Turner, M.-H. Stern, J. W. Said, C. T. Denny, and R. Wall
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues
PNAS,
August 17, 1999;
96(17):
9809 - 9814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Maggiorella, F. Monardo, M. L. Koanga-Mogtomo, L. Cioe, L. Sernicola, F. Corrias, C. D. Baroni, P. Verani, and F. Titti
Detection of Infectious Simian Immunodeficiency Virus in B- and T-Cell Lymphomas of Experimentally Infected Macaques
Blood,
May 1, 1998;
91(9):
3103 - 3111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Moses, J. Nelson, and G. C. Bagby Jr
The Influence of Human Immunodeficiency Virus-1 on Hematopoiesis
Blood,
March 1, 1998;
91(5):
1479 - 1495.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Yates, K. Sabe, C. Arzubiaga, S. Raffanti, and L. King
Rapidly Progressing Nodule in a Patient With the Acquired Immunodeficiency Syndrome
Arch Dermatol,
December 1, 1994;
130(12):
1556 - 1556.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. K. Burns
Topical Review Article: The Neuropathology of Pediatric Acquired Immunodeficiency Syndrome
J Child Neurol,
October 1, 1992;
7(4):
332 - 346.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. D. Kaplan, D. I. Abrams, E. Feigal, M. McGrath, J. Kahn, P. Neville, J. Ziegler, and P. A. Volberding
AIDS-Associated Non-Hodgkin's Lymphoma in San Francisco
JAMA,
February 3, 1989;
261(5):
719 - 724.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. M. KNOWLES, G. A. CHAMULAK, M. SUBAR, J. S. BURKE, M. DUGAN, J. WERNZ, C. SLYWOTZKY, P. PELICCI, R. DALLA-FAVERA, and B. RAPHAEL
Lymphoid Neoplasia Associated with the Acquired Immunodeficiency Syndrome (AIDS) The New York University Medical Center Experience with 105 Patients (1981-1986)
Ann Intern Med,
May 1, 1988;
108(5):
744 - 753.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. T. Headington, M. S. Roth, D. Ginsburg, A. S. Lichter, D. Hyder, and B. Schnitzer
T-Cell Receptor Gene Rearrangement in Regressing Atypical Histiocytosis
Arch Dermatol,
September 1, 1987;
123(9):
1183 - 1187.
[Abstract]
[PDF]
|
|
|
|
|
