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Iron metabolism in the Belgrade rat
J Edwards, H Huebers, C Kunzler and C Finch
Iron metabolism in the Belgrade rat was examined in the intact animal and
in the reticulocyte suspensions. The plasma iron turnover was increased.
However, when allowance was made for the effect of the elevated plasma iron
concentration, erythroid marrow capacity for iron uptake was at basal
levels. Numbers of erythroid cells in marrow and spleen measured by the
radioiron dilution technique were increased. Thus iron uptake was not
proportionate to the erythroid hyperplasia in the b/b rat, despite a more
than adequate plasma iron supply. This relative deficiency in iron uptake
was reflected in a severe microcytosis and elevated red cell
protoporphyrin. Reticulocyte incubation studies demonstrated an unimpaired
uptake of the transferrin- iron-receptor complex but a marked reduction in
iron accumulation. The diferric transferrin molecule, when it did give up
iron within the cell, released both of its iron atoms so that only
apotransferrin was returned to the media. In contrast to the nearly
complete release of iron within the normal reticulocyte, the major portion
of iron taken up by the Belgrade reticulocyte was returned to the plasma.
The release mechanism that can be impaired in iron-deficient reticulocytes
by EDTA or cadmium was shown to be affected by lower concentrations of
these substances in the Belgrade reticulocyte. It is concluded that the
Belgrade rat has an abnormality of iron release within the absorptive
vacuole that is responsible for a state of intracellular iron deficiency,
involving the erythron and other body tissues.
Volume 67,
Issue 3,
pp. 623-628,
03/01/1986
Copyright © 1986 by The American Society of Hematology
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