Survival and recovery of human platelets stored for five days in a non-
plasma medium
GA Adams, SD Swenson and G Rock
Human blood platelets were stored for five days as concentrates in 60 mL
of: (a) plasma; (b) non-plasma medium with anticoagulant; and (c)
non-plasma medium without anticoagulant. All preparations were equally
functional when tested for platelet aggregation and release reaction in
response to single agonist or synergistic pairs of agonists in vitro.
Platelets stored in non-plasma medium with anti-coagulant had lower
kallikrein, fibrino(gen)peptide A, lactate, and beta-thromboglobulin than
did plasma controls after five days. In vivo recovery and survival of
platelets stored in non-plasma medium with anticoagulant were 51.2% +/-
4.3% and 8.7 +/- 0.3 days, respectively, which were not statistically
different from plasma controls of 39.2% +/- 4.9% and 7.2 +/- 0.8 days,
respectively. It is concluded that platelets can be stored for five days in
a non-plasma medium and still have good in vivo recoveries and survivals.
Volume 67,
Issue 3,
pp. 672-675,
03/01/1986
Copyright © 1986 by The American Society of Hematology
