Lymphocyte malignancy and chromosome 14: structural aberrations involving
band q11
N Clare, D Boldt, G Messerschmidt, P Zeltzer, K Hansen and L Manhoff
Five patients with lymphocytic malignancies were found to have structural
aberrations of chromosome 14, all involving band q11. The malignant cells
of all five cases were analyzed by immunofluorescence to establish
immunologic phenotypes. Three patients had T lymphoblastic
lymphoma/leukemia with mediastinal masses (cases 1, 2, and 3); one patient
had peripheral T cell lymphoma (case 4); and one patient had acute
lymphocytic leukemia, common acute lymphoblastic leukemia antigen positive
(case 5). Although aberrations of chromosome 14 frequently are associated
with lymphocytic malignancies, these abnormalities most often result in
extra material on the long arm, 14q+. However, none of the five patients
reported here had a 14q+. Cases 1 and 2 had t(9;14)(q34;q11) and
t(11;14)(p11 or 13;q11), respectively. Case 3 showed del(14)(q11), and
cases 4 and 5 showed inv(14)(q11q32). Structural aberrations resulting in
14q- and inv(14) appear to occur infrequently. The five cases in this
report, in conjunction with those found in the literature, indicate a
strong association between breaks at 14q11 and T lymphocytic malignancies.
Volume 67,
Issue 3,
pp. 704-709,
03/01/1986
Copyright © 1986 by The American Society of Hematology
