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Hemoglobin switching during murine embryonic development: evidence for two
populations of embryonic erythropoietic progenitor cells
PM Wong, SW Chung, SM Reicheld and DH Chui
Explants of normal mouse embryonic tissues and disaggregated embryonic
single cells were cultured in vitro to study the erythropoietic progenitor
cells present during embryonic development. The results indicate that there
are two populations of erythropoietic progenitor cells committed to
different hemoglobin synthetic programs. These progenitor cells are present
at an early gestational stage prior to the formation of the fetal hepatic
primordium. One population of progenitors can be stimulated by
erythropoietin alone to form usually small erythroid colonies after culture
for six days in vitro. These erythroblasts primarily synthesize embryonic
hemoglobins, but produce some adult hemoglobins as well. The other
population of progenitors requires stimulation by both erythropoietin and
adult spleen cell- conditioned medium, and usually forms large erythroid
colonies after culture for six days in vitro. These erythroblasts produce
only adult hemoglobins.
Volume 67,
Issue 3,
pp. 716-721,
03/01/1986
Copyright © 1986 by The American Society of Hematology
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