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Controlled trial of desmopressin in liver cirrhosis and other conditions
associated with a prolonged bleeding time
PM Mannucci, V Vicente, L Vianello, M Cattaneo, I Alberca, MP Coccato, E Faioni and D Mari
The synthetic vasopressin derivative desmopressin (DDAVP) shortens a
prolonged bleeding time (BT) in patients with uremia, congenital platelet
dysfunction, and von Willebrand disease. To establish the limits of the
clinical usefulness of DDAVP, a controlled randomized study was carried out
in 53 patients and ten volunteers with different conditions that have in
common a prolonged BT. DDAVP significantly shortened the BT in 21
cirrhotics (P less than .01), in eight patients with unclassified prolonged
BT (P less than .05) and in ten volunteers taking the antiplatelet drugs
aspirin (P less than .05) and ticlopidine. The BT changes were not
statistically significant in 15 patients with severe thrombocytopenia nor
in nine with congenital platelet dysfunction, even though a few patients
with storage pool deficiency responded with a marked BT shortening. Our
findings indicate that DDAVP might be given when biopsies or other surgical
procedures must be carried out in patients with prolonged BT. However, the
compound is often ineffective in patients with thrombocytopenia or
congenital platelet dysfunction.
Volume 67,
Issue 4,
pp. 1148-1153,
04/01/1986
Copyright © 1986 by The American Society of Hematology
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