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Clinical and phenotypic diversity of T cell lymphomas
SJ Horning, LM Weiss, GS Crabtree and RA Warnke
Forty-one cases of T cell lymphoma were identified on the basis of
morphology and the expression of two or more T cell antigens with an
absence of B cell markers. Mycosis fungoides and lymphoblastic lymphoma
were excluded. Marked clinical, morphological, and immunologic diversity
was observed. Cutaneous lymphoma was found in approximately 50% of the
patient group, and 27% had a prior history of dermatologic or immunologic
disease. No correlations among immunologic and morphologic phenotypes and
clinical course were apparent. Survival data was comparable to that of a
concurrent group of non-T cell lymphoma patients studied at this
institution, suggesting that, contrary to previous reports, T cell lymphoma
may not necessarily confer a more unfavorable prognosis. Prospective
studies using uniform treatments are necessary to address the clinical
significance of the T cell phenotype definitively, independent of
established histologic and clinical features.
Volume 67,
Issue 6,
pp. 1578-1582,
06/01/1986
Copyright © 1986 by The American Society of Hematology

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