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Clinical and phenotypic diversity of T cell lymphomas

SJ Horning, LM Weiss, GS Crabtree and RA Warnke

Forty-one cases of T cell lymphoma were identified on the basis of morphology and the expression of two or more T cell antigens with an absence of B cell markers. Mycosis fungoides and lymphoblastic lymphoma were excluded. Marked clinical, morphological, and immunologic diversity was observed. Cutaneous lymphoma was found in approximately 50% of the patient group, and 27% had a prior history of dermatologic or immunologic disease. No correlations among immunologic and morphologic phenotypes and clinical course were apparent. Survival data was comparable to that of a concurrent group of non-T cell lymphoma patients studied at this institution, suggesting that, contrary to previous reports, T cell lymphoma may not necessarily confer a more unfavorable prognosis. Prospective studies using uniform treatments are necessary to address the clinical significance of the T cell phenotype definitively, independent of established histologic and clinical features.

Volume 67, Issue 6, pp. 1578-1582, 06/01/1986
Copyright © 1986 by The American Society of Hematology


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  Copyright © 1986 by American Society of Hematology         Online ISSN: 1528-0020